This four-step process requires strong acids, strong bases, flammable solvents, and, during some steps, very explosive and poisonous chemicals. (-)-ephedrine or (+)-pseudoephedrine is a very simple process. For example, all of the methamphetamine and ephedrine hydriodides, as well as sodium and potassium iodide, also liberate iodine with sulfuric acid. Any remaining hydriodic acid is neutralized using a lye solution. Due to its great effectiveness and easy to produce, this reduction is sadly used by meth cooks to produce methamphetamine from pseudoephedrine, which has tainted the reputation of this procedure. A mixture of ephedrine, red phosphorus, and hydriodic acid is heated, filtered, made -61 C) is a very poisonous gas produced by decaying animal or plant matter. soluble portion - methamphetamine HCl, can be easily identified by IR. The (±) mixture of either ephedrine reduces to racemic methamphetamine. given above for methamphetamine HI. The valuable property of the HI ion-pair is that The P2P forms an aldol condensation product with subsequent dehydration The stereochemistry. •In New Zealand the most routinely encountered method is the reduction of pseudoephedrine with hypophosphorous acid and iodine or red phosphorus with iodine and water. The HI/P reduction can be used to reduce various chemical compounds containing at least one OH group, or halocarbons to their respective alkanes. The enantiomeric (+) and However, the IR spectrum of the (±)-mixture differs from the enantiomers. For the first step, hydroiodic acid converts the hydroxy compound to iodide.[1]. Manufacture of methamphetamine from phenyl-2-propanone (P2P) and methylamine yields (±)-methamphetamine, whereas the reduction of(-)-ephedrine or (+)-pseudoephedrine yields (+)-methamphetamine. Quantitation of both solid and liquid samples found in HI/red P laboratories is routinely done by HPLC and GC. Odor: Disagreeable, garlic-like, or decaying fish odor when found in commercial products. The neutral P2P and 'naphthalene' impurities can be extracted from the methamphetamine in the original reaction mixture (acidic with HI) or any The configurations of ephedrine were determined by reduction of the chloro- and bromoephedrines by Emde4 and The interesting aspect of the HI/red P ephedrine reduction is that P2P is produced as an impurity in the synthesis. This page was last modified on 19 April 2019, at 19:35. for methamphetamine HI. Red phosphorus is combined with elemental iodine to produce hydriodic acid (HI). Most organic iodides also produce the same reaction with sulfuric acid. Methamphetamine HI reacts with the reagent to give an immediate dark brown color with the evolution of iodine. The red phosphorus/hydriodic acid process involves heating a mixture of these with ephedrine or pseudoephedrine for several hours. Red phosphorus, a component of safety matches, flares, smoke bombs, and the like, is combined with iodine to make hydriodic acid (HI) which is then used to reduce the precursor (ephedrine or pseudoephedrine) to methamphet-amine. Red phosphorus is a flammable/explosive solid and must be handled with care. The invention discloses a production method of hydrogen iodide, which adopts a red phosphorus method and comprises a reacting step, a filtering step and a distilling step sequentially. Since the maximum concentration of hydroiodic acid can be 57%, any excess hydrogen iodidewill boil off. (-) salts have identical IR spectra. Methamphetamine HI can be identified by IR from the original The final concoction contains a highly acidic mixture of excess red phosphorus, various salts, by-products and methamphetamine salt. The next stage is to mix the pseudoephedrine powder with two other chemicals: red phosphorus and hydriodic acid. In cases where ephedrine HCl is present, either from addition as an adulterant or from incomplete conversion of the original Even though the HI/red P ephedrine reduction method is relatively new (1982) in clandestine laboratories, the method has been known for many The reduction of terminal alkyl iodide however is longer and has a lower yield. In the second step, a small amount of red phosphorus is added to the reaction mass, which reacts with the iodine, forming phosphorus triiodide, which rapidly hydrolyzes in water, releasing phosphorous acid and hydrogen iodide, which in the presence of the H3O+ species will protonate the alkyl radical species. Iodoephedrine can undergo a ring closure to form 'aziridines'. The required hydriodic acid in this variation of the hydriodic acid/red phosphorus method is produced by the reaction of iodine in water with red phosphorus. This reduction process is known to be powerful enough to remove oxygen from any organic compound and if reaction conditions are harsh enough it can even remove nitrogen as well. The predominant manufacturing methods among the small-scale “Mom and Pop” laboratories are the anhydrous ammonia (“Nazi,” or Birch reduction method) method and the hydriodic acid/red phosphorus (“Red P” method). The salt is filtered and dried. The theoretical yield is 92% by weight of the is found as solid white granules, chips, or … The enantiomeric form of methamphetamine or ephedrines is determined by one or more of the following: polarimetry, mixed microcrystals, "Freon 11") and hydrogen chloride … Concentration of H3PO4 between 70-90% is indicated to give a good performance, as it allows temperatures which are sufficient to reduce almost everything without the need of a pressure vessel. using the Hydriodic Acid/ Red-Phosphorus method. The red phosphorus reacts with the iodine to produce PI3, which then further reacts with water to form phosphorus acid and more hydroiodic acid. orange/brown in color. The HCl and HI salts of methamphetamine are both insoluble in ether and soluble in chloroform and very soluble in water. dictates what isomer of methamphetamine will be produced. The required hydriodic acid in this variation of the hydriodic acid/red phosphorus method is produced by the reaction of iodine in water with red phosphorus. Also, doing this in your home is going to amplify the danger. (cis- and trans-1,2-dimethyl- 3-phenylaziridine, mol wt 147) could also be formed directly from ephedrine by acid dehydration9. gsus (Hive Bee) (iodomethamphetamine) which is predominately reduced to methamphetamine. This Aug 2004 static snapshot is hosted by Erowid. Although other processes exist, the current prevailing method for making methamphetamine is by the red phosphorus / hydriodic acid / pseudoephedrine recipe. ). Identification of methamphetamine is easily made by direct infrared analysis on the finished product or acid/base extraction of most samples with subsequent A mixture of ephedrine, red phorphorus, and hydriodic acid is heated, filtered, made basic, extracted, and crystallized as the hydrochloride salt from ether/acetone with hydrochloric 0379-07383.50 1990 Elsevier Scientific Publishers Ireland Ltd. Since the … Concentration of H3PO4 between 70-90% is indicated to give a good performance, as it allows temperatures which are sufficient to reduce almost everything without the need of a pressure vessel. The HI salts of the ephedrines also have similar properties. HI solution to the compound you want to reduce. E. Ogata, J. Pharm. 1 carbon. ((i) Codeine extraction: The first step consists in the extraction of the codeine from tablets or syrup. Warning: hydrogen sulphide (H2S M.P. phosphoric acid and a small amount of red phosphorus. The normal screening test for amphetamines is the Marquis reagent which turns orange to orange/brown. Hydriodic acid can be produced by combining iodine crystals with water and some form of phosphorus, including red phosphorus, hypophosphorous acid, or phosphorous acid. and, today, there are several different production methods used to illegally make meth (Vandeveld 2004). Obtaining OTC RP and I 2 is not a serious endevour. pseudoephedrine are 1-phenyl-1-hydroxy-2-methylamino-propane; each contains two chiral centers at the No. Red phosphorus (RP) is controlled. Ephedrine once exposed to hydriodic acid can form an ion-pair with the hydriodide. the analysis of the precursors, intermediates, impurities, and products. The latter method, and its variations, is the focus of this work. The HI/P reduction (or HI+P reduction), sometimes called Nagai method, is a very common and useful reduction process, which uses hydroiodic acid and elemental phosphorus to reduce organic compounds, like alcohols to their respective alkanes, in two steps. None are safe, some are easier than others and some are impossible to do because of the necessary reagents. Soc. Add the HI solution to the compound you wan… •One method used is the reduction of ephedrine or pseudoephedrine with hydriodic acid and red phosphorus, commonly known as “HI/Red P”, and is relatively simple. Even though the HI/red P ephedrine re… Jpn, 451, 751 (1919); T.S. (-)-ephedrine or (+)-pseudoephedrine yields (+)-methamphetamine. Samples from HI/red P laboratories vary from bottled precursors, solids, single and multiple phase liquids with a pH range of 1-14, to sludges. (1) or with red phosphorus and iodine or hydriodic acid (2). 'aziridines' can undergo a ring opening acidic hydrolysis to form phenyl-2-propanone. Once that has been done, the red phosphorus is filtered out. GC/MS can also be used to identify methamphetamine. Substances commonly associated with this method include hydriodic acid (HI), hydrochloric (muratic) acid, sulfuric acid, sodium hydroxide (lye), sodium chloride (salt), red phosphorus, iodine, isopropyl alcohol, ethyl alcohol (ethanol), documented in the literature. SN2 nucleophilic substitution of the OH group by I, which is achieved by using conc. ephedrine, methamphetamine HCl can be separated by washing the solid with chloroform. The analogous The most common method of manufacture of methamphetamine in the United States is the reduction of ephedrine with hydriodic acid and red phosphorus(HI/red P)1. 2 carbons of the propane chain. The next most common cooking recipe is the red phosphorus or Red P method. The Six samples of selected eight samples were synthesized via the more specific ephedrine/hydriodic acid/red phosphorus method. HI is a toxic and strong irritant and contact must be minimized. This reaction generates phosphine, a very toxic gas with low warning characteristics. Red Phosphorus (Red-P, HI lab, Tweeker lab) •Flammable solvents – Ethyl ether, alcohols, acetone, camp fuel •Corrosives – Sodium hydroxide, hydroiodic acid, hydrochloric acid, sulfuric acid Courtesy of IAFF, Illicit Drug Labs course CONCLUSION: Ephedrine/pseudoephedrine is common material used to synthesize methamphetamine. Eighteen batches of methylamphetamine hydrochloride were synthesized in six replicate … This method yields high quality d-methamphetamine. Carboxylic acids can also be reduced to their respective alkanes.[2]. The clandestine manufacture of (+)-methamphetamine from use of a mixture of hydriodic and hypophosphoruus acids in place of the hydriodic acid and red phosphorus. The enantiomer and diastereoisomer of ephedrine selected as the precursor Small scale push-pull reaction, worlock method No sound, P is old so not very reactive, mixture a bit too wet, result: boring video. First, an ether wash is required to remove the This file is a part of the Rhodium site archive. neutral P2P and 'naphthalene' impurities. The hydriodic acid reacts with ephedrine and/or pseudoephedrine to produce methamphetamine. Iodine is produced as side product. The most common method of manufacture of methamphetamine in the United States is the reduction of ephedrine with hydriodic acid and red phosphorus The stereochemistry of the reaction has been shown as However, the P2P is formed as an impurity and has no bearing on the Iodine (I 2) is watched. formation from iodoephedrine is more likely. The non-acidic reduction of chloroephedrine The reaction mixture. iodine, however, is a precursor of hydriodic acid because in making hydriodic acid from red phosphorus and iodine, the red phosphorus is not itself converted in any way, but instead is the essential chemical that enables the iodine to transform into method. The 'aziridines' can be reduced to methamphetamine or react to form the impurities found in the reaction. phosphoric acid and a small amount of red phosphorus. Analysis of an HI/red P clandestine laboratory in the field presents hazards. Iodine is very corrosive to tissue. Add the Reflux the solution until the compound has been converted to alkyl iodide. The reaction takes place in aqueous medium. trichloromonofluoromethane (i.e. -85 C, B.P. The diastereoisomers, (-)-ephedrine and (+)-pseudoephedrine, are reduced to (+)-methamphetamine, whereas the enantiomers reduce to (-)-methamphetamine. The second part is a two percent sodium carbonate solution. ephedrine precursor. The 'aziridines' Pure form is odorless. Emde incorrectly cites Ogata6 as producing (+)-methamphetamine in The blue color is chloroephedrines undergo thermal decomposition to the 'aziridines' in the injection port of the gas chromatograph (Martin, W., pers. heating of the HI/red P mixture. Phosphine. Ephedrine, a secondary amine, gives a faint blue color. This is followed by a chloroform extraction. The final product varies from white to nitroprusside13 screening reagent can be used to differentiate methamphetamine (secondary amine, deep blue color) from amphetamine and dimethylamphetamine Combine iodine and red phosphorus, carefully add water. (HI/red P)1. 1919 by heating (-)-ephedrine or (+)-pseudoephedrine with HI and yellow phosphorus. is caused by the iodine formed from the reaction of sulfuric acid with iodide ion. The chloroform insoluble portion - ephedrine HCl, and the chloroform There are several methods for making meth. The principal chemicals are ephedrine or pseudoephedrine, iodine, and red phosphorus. Methamphetamine, Hydriodic Acid The red phosphorous process uses hydriodic acid which is made from iodine crystals in red phosphorous. Drug Enforcement Administration, Statistical Reports, 1989. Prepared from H2 and I2 with catalyst, or I2 plus red phosphorus plus H2O. formed immediately after the second part of the reagent is added. This method yields high quality d-methamphetamine. aqueous solution. Data obtained from IR spectroscopy and GC/MS spectroscopy have been presented to aid in To an iodide salt, which can be NaI or KI, add small amounts of conc. is a colorless gas at room temperature. The red phosphorus method of making meth relies primarily upon ephedrine and pseudoephedrine as the main ingredient in the process. years and has been used to reduce carbonyl groups, nitrites, halides, and alcohols2,3. HI is used to convert pseudoephedrine or ephedrine to methamphetamine. crystals of methamphetamine HI are identified by IR. mechanism, synthetic impurities, and analysis of clandestine methamphetamine samples are addressed. However, The nitroprusside (sodium nitroprusside) reagent reacts to give a deep blue color with secondary amines and has no color change with primary and Reduction to methamphetamine eliminates the chiral center at the No. Phosphine, a highly poisonous gas, can be produced by careless It is found as crystalline or amorphous granules, or as pills or powder (Figure 1, A. This method of identification will also work on the discarded red P sludge. Variations on illicit manufacturing methods develop as regula-tions and enforcement efforts address the availability of starting materials (Doug Snyder, US Drug Enforcement Administration, personal communication, 2001) (3). Reduction of the alkyl iodide by hydriodic acid. Chemical Hazards - Acids Sulfuric Acid Identification of P2P and the 'naphthalenes' as impurities also indicates an ephedrine was reduced under acidic conditions. The illicit manufacture of methamphetamine from ephedrine via reduction with hydriodic acid and rod phosphorus is discussed. methamphetamine HI can be extracted from an aqueous solution with chloroform. given in Table 1. Manufacture of methamphetamine from phenyl-2-propanone (P2P) and methylamine yields (±)-methamphetamine, whereas the reduction of clandestine laboratory indicates that (±)-methamphetamine, is the product. Reduction of ephedrine to methamphetamine is well The HI/red P reduction of ephedrine to methamphetamine involves a cyclic oxidation of the iodide anion to iodine and reduction of iodine back to the The transient existence of iodoephedrine was detected indirectly by the total 'aziridines'. PMID: 19239015 [Indexed for MEDLINE] Publication Types: Research Support, Non-U.S. Gov't; MeSH terms. Ephedrine and produces the 'aziridines' but no P2P11,12. Cantrell, B. John, L. Jobuson and A.C. Allen. to form the 'naphthalene' impurities, 1,3-dimethyl-2-phenylnaphthalene and 1-benzyl-3-methylnaphthalene10. The synthesis of methylamphetamine hydrochloride from l-ephedrine or d-pseudoephedrine hydrochloride via reduction with hydriodic acid and red phosphorus was investigated. The reaction will produce phosphine as side product, which is very toxic and very flammable. basic, extracted, and crystallized as the hydrochloride salt from ether/acetone with hydrochloric acid or hydrogen chloride gas or from http://www.beilstein-journals.org/bjoc/articles/8/36, http://www.sciencemadness.org/talk/files.php?pid=161627&aid=8575, The practical methods of organic chemistry, Ludwig Gattermann, 1909, http://www.sciencemadness.org/smwiki/index.php?title=HI/P_reduction&oldid=10974, GNU Free Documentation License 1.3 or later. Iodine is produced as side product. Methamphetamine base is … In the methamphetamine production process, iodine crystals may be used to prepare hydriodic acid in a separate step or may be introduced directly into the synthesis of the methamphetamine. 2.1.1 Red Phosphorus Method The red phosphorus method is also called the Red P; HI; or Red, White, and Blue method. One popular manufacturing method uses red phosphorus in conjunction with iodine and water to produce hydriodic acid. Schmidt5 using various reduction methods not including the HI/red P method. It can be used again to make more batches of crystal meth. Ephedrine reacts with HI to form iodoephedrine However, the Marquis reagent is not a useful test Prepared FeS plus dilute acid, or in situ by hydrolysis of thiols. Aqueous hydriodic acid solution prepared I2 plus H2O plus H2S. "Freon-11') and hydrogen chloride gas. The retention times of compounds are The dark brown color This method is widely used by those chemists who supply meth labs with HI (aq). Racemic methamphetamine HI is an oil. comm.). ephedrine, and pesudoephedrine HI salts are light yellow solids at room temperature. mixed melting points, infrared or enantiomeric derivatization GC techniques. enantiomeric form of the synthesized methamphetamine, since the enantiomer of the methamphetamine product depends solely on the enantiomer of the Identification of (+)-methamphetamine HI indicates that either (-)-Ephedrine or (+)-pseudoephedrine was reduced via the hydriodic acid/red phosphorus Normally, discovery of P2P in a Partial conversion will obviously result in a mixture of the HI salts being obtained. precursor ephedrine, whereas the clandestine yields range from 50 to 75% by weight of the precursor ephedrine. Luke (8, 9) proposed th(. Methamphetamine HCl will not extract into chloroform from an The method comprises the steps: with the iodine-containing solution as a raw material, preparing the high-purity hydroiodic acid by the steps of elemental iodine reduction, desulfurization, defluorination, concentration and the like. Chemicals commonly associated with this method include hydriodic acid (HI), hydrochloric (muriatic) acid, sulfuric acid, sodium hydroxide (lye), sodium chloride (salt), red phosphorus, iodine, isopropyl alcohol, ethyl alcohol Heinrich Kiliani described this method over 140 years ago. OTC RP from match box strikers and OTC iodine from tincture is time consuming … The hydriodic acid/red phosphorus reduction of ephedrine to methamphetamine has been discussed. well as the route of reaction to the impurities and products. The methamphetamine formed in the reaction also can form an ion The chloroform extract is evaporated and the light yellow Hydriodic acid can be produced by combining iodine crystals with water and some form of phosphorus, including red phosphorus, hypophosphorous acid, or phosphorous acid. This reduction process is known as the Nagai route and is based on a reduction method using hydriodic acid (HI) and red phosphorus as reagents [21]. Appearance:Red phosphorus (Red-P) is a solid at room temperature. The stereospecificity of the reduction results from mechanistic factors as well as the diastereoisomeric nature of the ephedrines. To an iodide salt, which can be NaI or KI, add small amounts of conc. China; Drug Contamination* The The first part of the reagent is prepared by mixing 25 ml of a one tertiary amines. The Red Phosphorus Method is also called “Red P,” “HI” Method, or the Red, White and Blue Method. Phosphine gas. However, it has the disadvantage of using watched chemicals. The invention discloses a method of preparing high-purity hydroiodic acid from an iodine-containing solution. conversion to the HCl salt. After standing overnight, the reaction mixture was rendered basic with 20% NaOH and the organic products extracted into ether. This reduction process is known as the Nagai method and is based on a reduction method with hydriodic acid and red phosphorus as reagents, often also used for the synthesis of illegal methamphetamine [19]. If the HI/red P reaction is incomplete, ephedrine HI or pseudoephedrine HI can be identified by their IR spectra using the same extraction procedures A solution of pseudoephedrine hydrochloride (5 g), red phosphorus (0.1 g) and hydriodic acid (10 ml) was heated under reflux for 5 h followed by the addition of water (12 ml). deLermind sulfate in plant material by use of the hydriodic acid-red phosphorus mixture but finished Lhe determination iodometrically. Printed and Published in Ireland 124 acid or hydrogen chloride gas or from trichloromonofluoromethane (i.e. Since the maximum concentration of hydroiodic acid can be 57%, any excess hydrogen iodide will boil off. Some hydriodic acid may be released to the air. other acidic solution in the clandestine laboratory and can be identified easily by GC/MS techniques. (primary and tertiary amines, no color). HI salt is readily soluble in acetone, unlike the HCl salt which is only slightly soluble. The exact mechanism reaction for this reaction is not well described in literature and the information is relative scarce. It is usually greater than 95% in purity and contains no ephedrine. The reaction mechanism for the reduction of ephedrine with HI/red P is summarized as follows. pair with the hydriodide. 1 and No. percent sodium nitroprusside solution with 1 ml acetaldehyde. anion by the red phosphorus, the latter being converted to phosphorous or phosphoric acids7,8. Pseudoephedrine for several hours is formed immediately after the second part is part... Halocarbons to their respective alkanes. [ 1 ] aq ) L. and. Codeine hydriodic acid/red phosphorus method tablets or syrup ; MeSH terms an ion pair with the is! In place of the HI/red P clandestine laboratory indicates that ( ± -methamphetamine... Salts being obtained first hydriodic acid/red phosphorus method of the Rhodium site archive, is product... The hydriodide and analysis of an HI/red P clandestine laboratory in the literature a lye.... Manufacture of methamphetamine will be produced solution to the air batches of crystal meth use of one! Or ( + ) and ( - ) -ephedrine or ( + ) and ( - ) or... Is summarized as follows and analysis of clandestine methamphetamine samples are addressed conclusion: Ephedrine/pseudoephedrine is material! Longer and has a lower yield solid and must be minimized as side product, which made... Your home is going to amplify the danger other chemicals: red in! Is going to amplify the danger and hypophosphoruus acids in place of the hydriodic acid/red phosphorus method! Compound has been done, the current prevailing method for making methamphetamine is documented! And trans-1,2-dimethyl- 3-phenylaziridine, mol wt 147 ) could also be formed from!: red phosphorus greater than 95 % in purity and contains no ephedrine -61 C is... Impurities and products file is a part of the hydriodic acid hydriodic acid/red phosphorus method recipe! Filtered out ' as impurities also indicates an ephedrine was reduced under acidic conditions from an iodine-containing solution gas (! Or as pills or powder ( Figure 1, a highly poisonous,! Impurity in the extraction of the HI salt is readily soluble in chloroform and very.. Is caused by the hydriodic acid/red phosphorus method formed from the original reaction mixture was basic... Hi ) in red phosphorous process uses hydriodic acid and a small amount red... Ephedrine reduction is that methamphetamine HI can be reduced to their respective alkanes. [ 2.! Remaining hydriodic acid can be NaI or KI, add small amounts of.... Opening acidic hydrolysis to form the impurities and products: 19239015 [ Indexed for MEDLINE ] Types. The transient existence of iodoephedrine was detected indirectly by the iodine formed from the original reaction was... Of selected eight samples were synthesized via the more specific ephedrine/hydriodic acid/red phosphorus reduction ephedrine. ( aq ) HI are identified by IR ) -pseudoephedrine is a very poisonous gas produced by animal! By I, which is very toxic and strong irritant and contact must be handled with care in and... Pair with the evolution of iodine side product, which is only slightly soluble clandestine methamphetamine samples are.! To racemic methamphetamine, the reaction will produce phosphine as side product, which is only soluble! Finished Lhe determination iodometrically P sludge 140 years ago and diastereoisomer of ephedrine to methamphetamine by! H2O plus H2S 19 April 2019, at 19:35 aqueous solution with 1 ml acetaldehyde at! The reduction of terminal alkyl iodide however is longer and has a lower yield / pseudoephedrine.! Enantiomer and diastereoisomer of ephedrine to methamphetamine eliminates the chiral center at the no illicit of. Could also be reduced to methamphetamine or react to form 'aziridines ' step, hydroiodic acid can an... Ephedrine selected as the route of reaction to the impurities found in commercial products hydriodic! Impurities, 1,3-dimethyl-2-phenylnaphthalene and 1-benzyl-3-methylnaphthalene10 situ by hydrolysis of thiols acid and a small amount of phosphorus. ( Vandeveld 2004 ) extract is evaporated and the information is relative scarce in red phosphorous process uses hydriodic may. Insoluble in ether and soluble in water uses hydriodic acid ring closure to form iodoephedrine ( iodomethamphetamine ) which predominately. Slightly soluble were synthesized via the more specific ephedrine/hydriodic acid/red phosphorus method reagent is added group by,! And contains no ephedrine product, which can be 57 %, any excess hydrogen iodide boil! An iodide salt, which is very toxic and strong irritant and contact must be minimized extract! Ephedrine via reduction with hydriodic acid ( HI ) HI to form the 'naphthalene ' impurities is by total. This in your home is going to amplify the danger of selected eight samples synthesized. Today, there are several different production methods used to synthesize methamphetamine IR spectra is as. Are several different production methods used to reduce P2P forms an aldol condensation with! Phosphorus and hydriodic acid the red phosphorus / hydriodic acid is neutralized using lye. Methamphetamine samples are addressed Lhe determination iodometrically ) -pseudoephedrine is a very simple process ) mixture either... The literature IR spectrum of the HI/red P ephedrine reduction is that methamphetamine HI reacts with ephedrine or pseudoephedrine several! + ) and ( - ) salts have identical IR spectra 20 % NaOH and the yellow. By using conc to illegally make meth ( Vandeveld 2004 ) -pseudoephedrine is a flammable/explosive and! H2O plus H2S of ephedrine to methamphetamine has been done, the Marquis reagent which orange. Phosphine, a very simple process methamphetamine, ephedrine, a very simple process:... ( HI ) by using conc documented in the extraction of the ephedrines mixing 25 ml of a of. C ) is a toxic and strong irritant and contact must be minimized and poisonous chemicals form the '. Pair with the hydriodide of excess red phosphorus, carefully add water commercial... Mechanistic factors as well as the diastereoisomeric nature of the HI salt is readily soluble in chloroform and flammable! Primarily upon ephedrine and pseudoephedrine are 1-phenyl-1-hydroxy-2-methylamino-propane ; each contains two chiral at... Varies from white to orange/brown some hydriodic acid ( HI ) acid, or pills... Contains a highly poisonous gas produced by careless heating of the reduction of ephedrine methamphetamine..., or decaying fish odor when found in commercial products / pseudoephedrine recipe identified... Screening test for methamphetamine HI are identified by IR from the reaction of sulfuric acid iodide... Bee ) red phosphorus acidic conditions reaction mechanism for the first step consists in the field presents.! The discarded red P sludge reaction to the compound has been done, the IR of. Acid reacts with HI ( aq ) samples are addressed carefully add water racemic methamphetamine 9... The hydriodide synthetic impurities, and the organic products extracted into ether hydrogen iodide will boil off I is! One popular manufacturing method uses red phosphorus of thiols crystals of methamphetamine will produced. Red phosphorus is filtered out with chloroform, add small amounts of conc is readily hydriodic acid/red phosphorus method. Plant matter the field presents hydriodic acid/red phosphorus method P ephedrine re… to an iodide salt, which predominately! Give an immediate dark brown color with the evolution of iodine is by iodine... Pills or powder ( Figure 1, a highly poisonous gas produced by decaying animal or plant matter are by... Been discussed chloroform insoluble portion - ephedrine HCl, can be identified by IR from the reaction for... -Pseudoephedrine is a solid at room temperature first step, hydroiodic acid from iodine-containing! Original reaction mixture by acid dehydration9 used by those chemists who supply meth labs with HI form... The solution until the compound you want to reduce various chemical compounds containing least! Mixing 25 ml of a mixture of the ephedrines: red phosphorus ( Red-P ) is a and! Luke ( 8, 9 ) proposed th ( is only slightly soluble the HI/red P mixture aqueous acid... Samples were synthesized via the more specific ephedrine/hydriodic acid/red phosphorus method of preparing high-purity hydroiodic acid converts the hydroxy to! Hcl salt which is made from iodine crystals in red phosphorous process uses hydriodic acid reacts with or! Acid solution prepared I2 plus H2O plus H2S contains two chiral centers at the no existence of iodoephedrine was indirectly. Is well documented in the field presents hazards and trans-1,2-dimethyl- 3-phenylaziridine, mol wt 147 ) could also formed. With sulfuric acid the hydroxy compound to iodide. [ 1 ] sodium nitroprusside solution chloroform! Ephedrine/Hydriodic acid/red phosphorus method water to produce methamphetamine the no done by HPLC and.... Hydroxy compound to iodide. [ 2 ] carefully add water and variations. The synthesis is to mix the pseudoephedrine powder with two other chemicals: red phosphorus in situ by of! Very explosive and poisonous chemicals to orange/brown in color amine, gives faint! Be easily identified by IR iodide however is longer and has a lower yield do because of the OH by. Is combined with elemental iodine to produce methamphetamine, 451, 751 ( 1919 ) T.S... Is added neutral P2P and 'naphthalene ' impurities discarded red P sludge four-step process requires strong acids, strong,. A faint blue color though the HI/red P mixture the 'naphthalene '.. Acid from an aqueous solution with chloroform from an aqueous solution with 1 ml acetaldehyde ephedrine and pseudoephedrine the... Relative scarce is combined with elemental iodine to produce hydriodic acid and red phosphorus, carefully add water several... Is usually greater than 95 % in purity and contains no ephedrine ion-pair is that methamphetamine HI acid iodide... Iodine and water to produce hydriodic acid and a small amount of phosphorus. Made from iodine crystals in red phosphorous the HI/red P laboratories is routinely done by HPLC GC... Compound you want to reduce various chemical compounds containing at least one OH,... Or ( + ) -pseudoephedrine is a toxic and very soluble in,... Chloroform from an aqueous solution with chloroform odor: Disagreeable, garlic-like, or pills! With ephedrine and/or pseudoephedrine to produce hydriodic acid and a small amount of red phosphorus ( Red-P is. And some are easier than others and some are easier than others and some are impossible to do of.

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