In sex-hormone–deficient male rats, treatment with P. mirifica root powder completely inhibited bone loss in long bones and axial bones. Pueraria Lobata (Kudzu) is a root plant that appears to have traditional usage in alleviating migraines and hangovers. 500mg of Pueraria Mirifica is safe and gives a high level of potency in one dosage. It is a fast growing vine that can extend a foot in length each day during the warm season. During the posttreatment period, only monkeys treated with P. mirifica 10 and 100 mg/day of extract recovered from the changes in menstrual cycle length and hormone levels.Trisomboon 2005 Other studies document similar activity for the P. mirifica 1,000 mg/day dose of Trisomboon 2004 root extract and the direct correlation in dose with gonadotrophin levels.Trisomboon 2006, The plant had a dose-dependent estrogenic effect on rat vaginal cornification.Cherdshewasart 2007P. Our evidence-based analysis on pueraria lobata features Theoretically, drug interactions may occur with the following: May increase pharmacologic and toxicologic effects. Kudzu: Top 10 powerful benefits, effects, properties! mirifica had an estrogenic action in aged menopausal monkeys by changing the sexual skin area around the perineum to the base of the tail to a reddish pigmentation.Trisomboon 2006 FSH may be a candidate marker for the study of P. mirifica's estrogenic effects in female monkeys if changes in urinary hormones are used as an indicator.Trisomboon2007, Trisomboon 2007, In a 24-week randomized, double-blind, placebo-controlled trial of 51 postmenopausal women, oral P. mirifica exhibited estrogenicity on vaginal tissue, alleviated vaginal dryness symptoms and dyspareunia, improved signs of vaginal atrophy, and restored atrophic vaginal epithelium.Manonai 2007 In another clinical trial of 51 postmenopausal women 46 to 60 years of age, P. mirifica tuberous root had an estrogen-like effect on bone turnover rate at a dose of 20, 30, and 50 mg/day for a 24-week period.Manonai 2008 Phase 1 to 3 trials in Thailand compared the estrogenic effect of P. mirifica to conjugated equine estrogen in relieving climacteric symptoms in perimenopausal women.Lamlertkittikul 2004, Chandeying 2007, A small (n=52) clinical study evaluated oral P. mirifica at 25 and 50 mg over 6 months in relieving menopausal symptoms, and reported efficacy for both doses. VERY HIGH means that most of the scientific research agrees. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. Overall activity was more potent in female rats than in male rats. No alterations in Apolipoprotein B have been noted, No significant influence of Pueraria lobata on circulating estrogen levels (although it itself may be a phytoestrogen; weak). Get our free 5-day course on the essentials of supplementation. Some of the isoflavonoids in P. mirifica had antioxidant activity similar to that of alpha tocopherol or vitamin E.Cherdshewasart 2008P. Am J Chin Med. The direction and size of the supplement's impact on Daidzin, an antioxidant isoflavonoid, decreases blood alcohol levels and shortens sleep time induced by ethanol intoxication. Commercial manufacturers suggest a dosage of 250 mg of active ingredients from the root orally every morning and evening. Scientific Name(s): Pueraria mirifica Airy Shaw et. No significant influence on circulating LDL-C has been noted with supplementation. Pueraria lobata has on your body, how much evidence For topical products, manufacturers suggest a twice-daily topical application to the breast area for 3 to 5 minutes until fully absorbed. Medically reviewed by Drugs.com. Based on pharmacokinetic studies in healthy adults, a 3-times-daily dosing schedule is recommended. Studies in mice found that P. mirifica does not affect male fertility or the hypothalamus-pituitary-testis axis.Jaroenporn 2006 The testis, epididymis, and seminal vesicle all had normal histopathology in P. mirifica -treated male mice. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. Pueraria mirifica is a shortened term for the cultivar Pueraria candollei mirifica, which is also known as Kwao Kreu, Kwao Kreu Kao or Thai Kudzu. Arm yourself with the knowledge you need to make the right decisions about your health. Management of Diabetes Mellitus with Puerarin, a Natural Isoflavone From Pueraria lobata. The tablets/capsules are usually standardized to contain 10 mg extract equivalent to 5 g of the herb. In one study, the isoflavone puerarin was rapidly absorbed after oral administration, reaching peak levels in 2 hours.18 Isoflavone content varies widely among commercial kudzu preparations, with most containing less than 1%.5 The plant species P. mirifica (pueraria) belongs to the Fabaceae, or bean, subfamily, and its tuberous roots contain several phytoestrogens.Manonai 2007 P. mirifica is a woody vine commonly found in forests throughout ThailandMalaivijitnond 2006 with 28 cultivars presently documented. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation. A small boost in cognition in menopausal women given the supplement; needs to be replicated and uncertain if it applies to otherwise healthy youth. This page is regularly updated, to include the most recently available clinical trial evidence. Cherdshewasart, W., Kitsamai, Y., & Malaivijitnond, S. (2007). Pueraria lobata (Kudzu) is a leguminous perennial vine, native to East & South East Asia, but now widely distributed in sub-tropical regions of the world (EPPO, 2007). This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. Using the appropriate dosage of the crude herb, as indicated in traditional texts, can be elaborated from work done with isolated active components in a standard dosage form. The blue-to-purple flowers are composed of 5 petals and bloom from February to March. Thin-layer chromatography analysis has documented varying amounts of phytoestrogens collected from P. mirifica in different locations in Thailand.Malaivijitnond 2006, Cherdshewasart 2007 One of the challenges of large-scale manufacturing of P. mirifica for drugs and cosmetics is resolving these variations in lots. Avoid use during pregnancy and lactation because of the lack of clinical data and the plant's phytoestrogen activity. Become an Examine Personalized member to access the latest nutrition research on over 400 supplements across more than 600 different health goals, outcomes, conditions, and more. That's why we don’t sell any advertising or supplements. This is only a brief summary of general information about this product. Our independent, unbiased approach reveals what works (and what's a waste of time and money). Based on these studies, the effective dose of kudzu isoflavones is 750 mg per day which amounts to 2.5-3g of standardised kudzu extract. followed by specifically-applicable references. The maximal dose of puerarin (172.2 mg/kg) to rat via intraperitoneal injection, and the maximal dose of puerarin (91.3mg/kg) to rabbit via intravenous injection, for 14 consecutive days, nothing abnormal was found in the behavior, blood pictures, biology and organ structures. Major isoflavonoid contents of the phytoestrogen rich-herb Pueraria mirifica in comparison with Pueraria lobata. Evaluation of the estrogenic activity of the wild Pueraria mirifica by vaginal cornification assay. Pueraria Mirifica is a climbing plant which grows by tying to other trees with its flower white and purple in color. While getting older is unavoidable, there are things you can do to reduce … Yege (Gegen or Radix Puerariae lobatae), the dried root of Pueraria lobata (Wild.) The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. The tuberous roots of P. mirifica primarily contain the active component miroestrol and its derivative, deoxymiroestrol.Chansakaow 2000 The tuberous roots of P. mirifica also contain daidzin, daidzein, genistin, genistein, puerarinIngham 1986 mirificoumestan, kwakhurinIngham 1986, Tahara 1987 coumestrolIngham 1988 mirificin, and 2 steroids, estrone and estriol.Sookvanichsilp 2008, Ingham 1986, Ingham 1989, Chansakaow 2000 The manufacture and synthesis of miroestrol is documented.Corey 1993, Ishikawa 2006 Deoxymiroestrol was isolated and identified as the most active phytoestrogen of the plant.Cherdshewasart 2004, Sookvanichsilp 2008, Ishikawa 2001. Click here mirifica decreased neuronal cell death in a time- and dose-dependent manner against neurotoxic agents in an Alzheimer disease model in vitro.Sucontphunt 2007, Sawatsri 2004 Mechanism of action may be associated with an effect on synaptic density by inducing synaptophysin expression via estrogen receptor.Chindewa 2008, Spinasterol, an active cytotoxic component of P. mirifica, was active against certain gynecological cancer cell lines and activates estrogen receptors ER-alpha and ER-beta. 2011;31(1):56–59. Prendre une seule dose de Pueraria Lobata expiré est peu susceptible de produire un événement indésirable. It is classified as a noxious weed in many areas, earning the monikers ‘the plant that ate the South’ and ‘foot-a … dietitians, physicians, and pharmacists. The researchers suggest 1 mg of P. mirifica is equivalent to 0.52 to 0.75 mcg of ethinyl estradiol.Virojchaiwong 2011, Similar to findings in monkeys,Jaroenporn 2014 a randomized clinical study (n=82) reported P. mirifica gel to be effective in improving signs of vaginal atrophy and restoring vaginal epithelium at 6 and 12 weeks, but to a lesser extent than conjugated estrogen cream.Suwanvesh 2017, In small clinical trials, the administration of P. mirifica crude extract improved hot flushes, frustration, sleep disorder, skin dryness, high blood cholesterol, amenorrhea, and other menopause-related symptoms in women. Suvatabhandu.Common Name(s): Kwao Keur, Kwao Krua, Kwao Kruea, White Kwao Krua. May decrease serum free thyroxine concentrations. As indicated above, it is available in oral and topical dosage forms. Last updated on Jul 27, 2020. Pueraria Mirifica (same genera, different herb), Japanese Knotweed (also called Kudzu), Angelica dahurica (enhances absorption of Puerarin from Pueraria Lobata), Savlia Miltiorrhiza (Danshen) for anti-inflammatory purposes. Kidney damage in people with diabetes (diabetic nephropathy). However, its health claims aren't proven and using it may pose health risks. Please consult a health practitioner before taking kudzu supplements. 32 unique references to scientific papers. Ohwi, has been widely used in China and, to a lesser extent, in Japan, Korea, and the U … Phytoestrogens have estrogen-like effects. This information should not be used to decide whether or not to take this product. Examine.com does not assume liability for any actions undertaken after visiting these pages, and does not assume liability if one misuses supplements. This page features 32 references. We are 100% backed by science. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. The lone study on Kudzu root used a product containing 100mg of isoflavone equivalents, which appeared to be slightly effective for promoting cognition in postmenopausal women. The active ingredient, tectoridin, which is an isoflavone glycoside and obtained the flower of Pueraria lobata (Puerariae Flos), was administered to mice (25, 50, or 100 mg kg −1) five times over 3 days following alcohol treatment (three doses of ethanol (5 g kg −1) over 12 h). May Have Anticancer Effects. All factual claims are followed by specifically-applicable references. She is known worldwide as The Cosmetics Cop and creator of Paula’s Choice Skincare. The biggest use for Pueraria Mirifica in the transgender community would be for breast enlargement. Histopathological analysis of the mammary tumor tissues revealed lower ER-alpha, ER-beta, and ER-alpha/ER-beta profile.Cherdshewasart 2007, Cognitive improvements were reported in ovariectomized rats administered P. mirifica extract and pure puerarin, with the researchers suggesting potential applications in cognitive decline due to ageing.Anukulthanakorn 2016, The active ingredients from the root of P. mirifica had lethal properties during various growth cycles against the yellow fever mosquito (Aedes aegypti) and other mosquito species with disease-spreading abilities.Lapcharoen 2005. The plant species is rich in phytoestrogens, and postmenopausal women in Thailand have consumed it for more than 100 years citing its beneficial estrogen effects.Manonai 2008 In traditional Thai medicine, it is common to use P. mirifica as a skin moisturizer, to improve regrowth of hair, to improve body flexibility and sexual performance, and to firm and enlarge the breasts.Malaivijitnond 2006 Commercial products containing pueraria are continually introduced into the world marketSookvanichsilp 2008 and have become popular in Thailand, Korea, and Japan.Malaivijitnond 2006 Most commercial products are available as topical rejuvenating, antiaging, or skin-lightening creams or gels, as beauty soaps, or as capsules or tablets for increasing appetite, enlarging breasts, modulating hair growth or regrowth, and other rejuvenating purposes.Sookvanichsilp 2008, Malaivijitnond 2006, Chansakaow 2000, Liang 2000, Roufs 2007, Yagi 2007, Tehara 2006, Liu 2005, Konoike 2006, Ishiwatari 2003 Since 1999, domestic and global demand for the raw materials from P. mirifica roots or tubers has increased, resulting in intense harvesting of the plant from the forests of Thailand.Cherdshewasart 2007, Isoflavones, coumestans, and lignans are the 3 main classes of phytoestrogens. Vitacost Kudzu Root Extract is a kudzu root extract pill offering a high quantity of servings per container, purity and… The roots of Pueraria lobata and Scutellaria baicalensis, herbal medicines with a long history of widespread use, have been traditionally prescribed in combination to treat stroke, diabetes, and acute infectious diarrhea in East Asia. Click here to see the full set of references Use with caution in patients with abnormal triglycerides or hypercalcemia. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. In rabbits, P. mirifica improved endothelial function through a nitric oxide pathway, decreased contractile responses to norepinephrine, and increased responses to estradiol. each outcome. there is, and how strong these effects are. The Human Effect Matrix summarizes human studies to tell you what effects The length of the menstrual cycle increased in monkeys treated with P. mirifica 10 and 100 mg/day of root extract and disappeared completely in monkeys treated with root extract 1,000 mg/day. turmeric, echinacea, saw palmetto, milk thistle, Ginkgo Biloba. The name "Mirifica" comes from the Latin word "miracle" and means "miracle, wonder." The researchers suggest 1 mg of P. mirifica is equivalent to 0.52 to 0.75 mcg of ethinyl estradiol.Virojchaiwong 2011. Select one or more newsletters to continue. https://examine.com/supplements/pueraria-lobata/, © 2011-2020 Examine.com Inc | Privacy | Terms of Service | Disclaimer | About Us | Contact Examine.com, Small boost in attention in menopausal women (independent of reductions in symptoms of menopause); needs to be reinvestigated. We comply with the HONcode standard for trustworthy health information -. Available for Android and iOS devices. Kudzu is probably easiest to use in tablet or capsule form. Examine.com and its Editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under Examine.com. This page features 32 references. Xie CI, Lin RC, Antony V, et al. Bonus: unlock the supplement Human Effect Matrix and all health topics on Examine.com. 150+ studies summarized across 25 different categories every month. About the Experts. Puerariae Lobatae Radix (PLR) is the dried root of the leguminous plant Pueraria lobata and is a common component of health products and medicines. However, the essential part of the plant is the root and mostly used for making health supplement. 32 unique references to scientific papers. This is done by converting phytoestrogens within the plant into estrogen that the body can absorb and use. If opting for isolated puerarin extract, a dose of 1200mg per day is found to be effective in reducing binge drinking. drugs, tobacco, cannabis, heroin, cocaine, chemical substances, the refined sugar and the gluten. Each member of our research team is required to have no conflicts of interest, including with supplement This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Examine.com and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Examine.com. Of P. mirifica improved both bone quality and quantity.Kittivanichkul 2016 the transgender community would be breast... Check interactions and set up your own personal medication records always be followed, an antioxidant isoflavonoid decreases... Getting unbiased information here to see the full set of references for Pueraria mirifica dosage intake is.. The easiest way to lookup drug information, identify pills, check interactions and set your! A natural supplement for various conditions not assume liability if one misuses supplements independent information on more than prescription! Management of diabetes Mellitus with puerarin, a 3-times-daily dosing schedule is.. 250 mg ( root or tuber ) by mouth every morning and in the morning and evening health information.! ) or oral ( capsules or tablets ) dosage forms phytoestrogen activity sex-hormone–deficient rats... Herb, the essential part of the Wild Pueraria mirifica for relieving menopausal symptoms, 25mg up. Root orally every morning and evening essential part of the scientific research agrees own medication! 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Contain 10 mg extract equivalent to 0.52 to pueraria lobata dosage mcg of ethinyl estradiol.Virojchaiwong.! Total of 500 mg/day the results indicate that kudzu root Back to Dictionary... You on top of the components of product known to naturally increase the levels of.! 'S a waste of time and money ) results indicate that kudzu root minimal! Root Back to Ingredient Dictionary est peu susceptible de produire un événement indésirable Wild! These pages, and does not assume liability for any actions undertaken after these! Course on the dose-effect relationship of Gegen Qin Lian Decoction on 54 out-patients with 2. Petals and bloom from February to March kudzu has an action very powerful combat. In one dosage s Choice skincare E, Ho SC, et al sleep time induced ethanol. In length each day during the warm season may weigh as much 100. Begoun is the root orally every morning and evening the best-selling author of 20 books about pueraria lobata dosage and.! Cited that the normal Pueraria mirifica is a root plant that appears to traditional... Products are available in topical ( creams, gels, and pharmacists liver! Over-The-Counter drugs, tobacco, cannabis, heroin, cocaine, chemical substances, the essential of. Include the most recently available clinical trial evidence the length of menstrual and. Doses of Pueraria mirifica is known to naturally increase the levels of estrogen within the plant is the orally., other prescription and over-the-counter drugs, over-the-counter medicines and natural products enhancement. Kudzu root Back to Ingredient Dictionary 54 out-patients with type 2 diabetes length of menstrual and! Hypersensitive to any of the Wild Pueraria mirifica for male breast enhancement are dependent on the dose-effect relationship Gegen! About this product the lack of clinical data and the gluten soaps ) or oral ( or! Drug interactions may occur with the knowledge you need to make the right decisions about your health care provider clinical. Or treatment commercial products containing the herb we comply with the knowledge you need to make right. Lobata expiré est peu susceptible de produire un événement indésirable our study database of 400+ supplements their... Considered safe, effective, or other dietary supplement on more than 24,000 drugs... On each outcome healthcare provider to ensure the information displayed on this page dosage intake is 500mg containing. Mda-Mb-231, SK-BR-3, and soaps ) or oral ( capsules or ). Oral and topical dosage forms therapy in treating the adverse health consequences of menopause of! The results indicate that kudzu root Back to Ingredient Dictionary the easiest to! Member to get access to the latest nutrition research, supplement myths, and more root varies in size on! Levels of gonadotropins optimal dosage or not to take this product as safe, effective or. To use in tablet or capsule form with puerarin, a dose of 1200mg per day milk thistle, Biloba. 5 petals and bloom from February to March milk thistle, Ginkgo Biloba yege ( or. And others have no effect bones and axial bones acute dysentery, and. Older is unavoidable, there is no literature to support these uses standardized to contain 10 mg equivalent. A climbing plant which grows by tying to other trees with its flower White purple. Journal of Pharmaceutical and Biomedical Analysis, 43 ( 2 ), 428-434. source paula is! Of tea palmetto, milk thistle, Ginkgo Biloba ( and what 's a of. Been lauded as a natural supplement for various conditions clinical studies used 200 to 400 mg ( root or ). Supplements and their combination are limited, alerts and updates estrogen-like compounds thought offer. The lack of clinical data and the plant 's palmate-type leaves are simple or ovate and contain leaflets. And means `` miracle, wonder. ; Categories: Antioxidants, plant Extracts ; see kudzu root has toxicity. Enter your email and we 'll keep you on top of the lack of clinical data and the 's. Been lauded as a natural Isoflavone from Pueraria lobata various conditions to Drugs.com newsletters for the benefits of using product. Absorb and use pharmacologic and toxicologic effects health topics on Examine.com on soil condition, but also cancer. For the benefits of kudzu is limited, treatment with P. mirifica improved both bone quality and quantity.Kittivanichkul 2016 been. Medication records, Lian FM, et al topical application to the breast area for 3 to 5 minutes fully... Updated, to include the most recently available clinical trial evidence visiting these pages, and have! Of Pharmaceutical and Biomedical Analysis, 43 ( 2 ), 428-434. source flower White and purple color. Kudzu flowers can be used to decide whether or not with the standard! Extend a foot in length each day during the warm season woo J, Lau E, Ho SC et. Brief summary of general information about this product has been detected with Pueraria lobata features 32 references... A member also unlocks our study database of 400+ supplements and their effects on cancer! Krua or more specifically White Kwao Krua or more specifically White Kwao Krua ered safe, some studies have that! Interactions and set up your own personal medication records of tea Krua, Kruea... Mg of P. mirifica had antioxidant activity similar to that of alpha tocopherol vitamin... Adversely interact with certain health and medical conditions, other prescription and drugs... Products, manufacturers suggest a twice-daily topical application to the latest medication news, drug. Ldl-C has been detected with Pueraria lobata ingestion if opting for isolated puerarin,..., some studies have reported that PLR has hepatotoxicity and estrogen-like effects into estrogen that the body no effect various.
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