Tell your doctor if you or your child have recently spent time in a tropical climate or have unexplained diarrhea before receiving this medicine. Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. The presence of other medical problems may affect the use of this medicine. Using this medicine while you are pregnant can harm your unborn baby. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. These could be symptoms of a serious liver problem. Tell your doctor right away if you or your child have depression, mood swings, a false or unusual sense of well-being, trouble with sleeping, or personality changes while receiving this medicine. If your child is receiving this medicine, tell the doctor if you think your child is not growing properly. Tuberculosis, inactive—Use with caution. In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. Do not get close to them and do not stay in the same room with them for very long. When oral therapy is not feasible and the strength, dosage form, and route of administration of the drug reasonably lend the preparation to the treatment of the condition, the intramuscular use of DEPO-MEDROL (methylprednisolone acetate) is indicated as follows: Endocrine Disorders. A. Talk to your doctor right away if you or your child have more than one of these symptoms while receiving this medicine: blurred vision, dizziness or fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness. Cushing's syndrome (adrenal gland problem) or, Liver disease (eg, cirrhosis, hepatitis) or, Myasthenia gravis (severe muscle weakness) or, Stomach or bowel problems (eg, diverticulitis, ulcers, ulcerative colitis) or. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, eye or vision problems, lupus, skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. This study was conducted to evaluate the influence of route of administration upon the bioavailability and pharmacokinetics of methylprednisolone sodium succinate. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor). Methylprednisolone is available in variety of sizes from 1 mg to 32 mg. Your dose of this medicine might need to be changed for a short time while you have extra stress. 1. However, elderly patients are more likely to have liver, kidney, or heart problems, which may require caution and an adjustment in the dose for elderly patients receiving methylprednisolone injection. This medicine may cause changes in mood or behavior for some patients. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This content does not have an Arabic version. Initial dose: 20 to 60 mg injected into lesion; for larger lesions, 1 to 4 injections of 20 to 40 mg should be used to distribute dose.-The interval between injections varies with the type of lesion and duration of improvement produced by the initial injection. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. This site complies with the HONcode standard for trustworthy health information: verify here. Methylprednisolone injection is used in the management of multiple sclerosis (a disease in which the nerves do not function properly), lupus (a disease in which the body attacks many of its own organs), gastrointestinal disease, and certain types of arthritis. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. FOR INTRAMUSCULAR ADMINISTRATION. Make sure you tell your doctor if you have any other medical problems, especially: A nurse or other trained health professional will give you this medicine. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. This medicine is to be given only by or under the direct supervision of your doctor. This indicates that methylprednisolone is effective in reducing postoperative trismus and that the systemic application of methylprednisolone is more effective than local injection. Methylprednisolone injection provides relief for inflamed areas of the body. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter. Indications and Usage for Methylprednisolone Sodium Succinate Injection. Along with its needed effects, a medicine may cause some unwanted effects. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Methylprednisolone (brand name Medrol) is provided in prepackaged forms for oral use. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Following the intravenous injection of methylprednisolone sodium succinate, demonstrable effects are evident within one hour and persist for a variable period. Depo-Medrone may be used locally or systemically, particularly where oral therapy is not feasible. The dosage and length of treatment are based on your medical condition and response to treatment. Take this medication by mouth as directed by your doctor, usually with food or milk. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. If you or your child start to have a fever, chills, sore throat, or any other sign of an infection, call your doctor right away. Although the i.v. It is available as single-dose vials in two strengths: 40 mg/mL, 80 mg/mL. Both groups achieved satisfactory hearing improvement during the 3-month follow-ups, and their hearing gains were comparable at frequencies ranging from 250 to 8000 Hz. Although not all of these side effects may occur, if they do occur they may need medical attention. Methylprednisolone may also be injected into a muscle or into abnormal skin tissue. Blood or urine tests may be needed to check for unwanted effects. Methylprednisolone injection is used to treat severe allergic reactions. Your doctor may want you or your child to gradually reduce the amount you are receiving before stopping it completely. May make these conditions worse. Local injection of glucocorticoids (e.g., methylprednisolone, betamethasone) into the tissue near the carpal tunnel has been used in a limited number of patients to relieve symptoms (e.g., pain, edema, sensory deficit) of carpal tunnel syndrome †. Insert needle through target area of stopper until tip is just visible. Methylprednisolone is contra-indicated in systemic fungal infection and in systemic infection unless specific anti-infective therapy is employed. Check with your doctor right away if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. Aggression 2. agitation 3. blurred vision 4. decrease in the amount of urine 5. dizziness 6. fast, slow, pounding, or irregular heartbeat or pulse 7. headache 8. mental depression 9. mood changes 10. noisy, rattling breathing 11. numbness or tingling in the arms or legs 12. pounding in the ears 13. swelling of the fingers, hands, feet, or lower legs 14. trouble thinking, speaking, or walking 15. troubled breathing at rest 16. weight gain Using alcohol or tobacco with certain medicines may also cause interactions to occur. Each mL of these preparations contains: ## Thus, if constantly high blood levels are required, injections ... associated with this route of administration. For non-prescription products, read the label or package ingredients carefully. Directed delivery of high doses of steroids into the inner ear is suggested for its potential and known as intratympanic steroids therapy (IST). All rights reserved. Depo-Medrone may be used by any of the following routes: intramuscular, intra-articular, periarticular, intrabursal, intralesional or into the tendon sheath. A healthcare provider will give you this injection. Follow your doctor's directions carefully. Withdraw dose. While you are being treated with methylprednisolone injection, do not have any immunizations (vaccines) without your doctor's approval. Methylprednisolone may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. These include multiple sclerosis, rheumatoid arthritis, psoriasis, and ulcerative colitis. Methylprednisolone injection provides relief for inflamed areas of the body. Intrathecal administration of methylprednisolone produces excellent analgesia in a variety of pain-related disorders. This content does not have an English version. This product is available in the following dosage forms: Portions of this document last updated: July 01, 2020. 3.Aseptically add 1 mL Bacteriostatic Water for Injection, USP (with benzyl alcohol) for the 40 mg vial or 2 mL Bacteriostatic Water for Injection, USP (with benzyl alcohol) for the 125 mg vial. It has the potential to cause subcutaneous atrophy in the area administered. Reports of severe medical events have been associated with this route of administration. Drug information provided by: IBM Micromedex. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. If you are receiving this medicine for a long time, tell your doctor about any extra stress or anxiety in your life, including other health concerns and emotional stress. This medicine may cause an allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. The drug is also available as a 20 mg/ml and 40 mg/ml solution for injection. This formulation of methylprednisolone acetate has been associated with reports of severe medical events when administered by this route. Comments: Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. It works on the immune system to help relieve swelling, redness, itching, and allergic reactions. Steroid medication can weaken your immune system, making it easier for you to get an infection. This medicine may cause you or your child to get more infections than usual. Depo-Medrol® and some strengths of Solu-Medrol® injection should not be used in premature infants. Intravenous or Intramuscular dosage (methylprednisolone sodium succinate injection) All rights reserved. Your doctor may give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. Methylprednisolone injection is also used to treat certain conditions that affect the blood, skin, eyes, nervous system, thyroid, kidneys, and lungs. Par-ticularly in developing countries, even in health care Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Infection (bacteria, virus, fungus, parasite, or protozoa)—May decrease your body's ability to fight infection. Methylprednisolone is availabe in tablets, an intravenous injection (methylprednisolone sodium succinate) and a “repositol” (longer-acting) injection form (methylprednisolone acetate). Fourteen healthy adult male volunteers received 40 mg doses of methylprednisolone as the following treatments after an overnight fast in … Receiving too much of this medicine or receiving it for a long time may increase your and your child's risk of having adrenal gland problems. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Using this medicine with any of the following medicines is not recommended. Methylprednisolone acetate injectable suspension is contraindicated for use in premature infants because the formulation contains benzyl alcohol. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of methylprednisolone injection in children. Upon the bioavailability and pharmacokinetics of methylprednisolone injection in the treatment of SSNHL therapy is not.! 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