Inducing genetic mutation. Important medical events that may not result in death, be life-threatening, or require hospitalization may be considered serious when, based upon appropriate medical judgment, they may jeopardize the patient or subject and may require medical or surgical intervention to prevent one of the outcomes listed in this definition. ¹ Source: wiktionary.com. Carcinogen definition, any substance or agent that tends to produce a cancer. Mutagenicity, Carcinogenicity and Impairment of Fertility. Adjective. In the 1960s, James & Elisabeth Miller et al. The adverse effects of enediynes on cells include mutagenicity (increase mutation), halting mitois (cell division) by arresting the cell cycle, and inducing apoptosis (programmed cell death). 7.14.1 Genotoxicity – ISO 10993–3. Mutagenicity tests synonyms, Mutagenicity tests pronunciation, Mutagenicity tests translation, English dictionary definition of Mutagenicity tests. It is based on mutagenicity in Salmonella bacteria. mutagenicity definition in English dictionary, mutagenicity meaning, synonyms, see also 'mutagenic',mutagen',mutability',mutagenesis'. Included in this broad definition are chemical and physical agents that cause mutagenicity, or transmissible genetic alterations, and genotoxicity. Citations with the tag: MUTAGENICITY testing Results 151 - 200. Read medical definition of Ames test. 1. Medical Definition of Mutagenicity tests. The Bacterial Reverse Mutation Assay (Ames test) is performed as part of the genotoxicity battery of tests to determine if leachables from a medical device/material are mutagenic. It achieves this by inhibiting Ca 2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. The National Library of Medicine (NLM), on the NIH campus in Bethesda, Maryland, is the world's largest biomedical library and the developer of electronic information services that delivers data to millions of scientists, health professionals and members of the public around the globe, every day. 1. Definition: A medical scientist who studies the various factors involved in the incidence, distribution, and control of disease in a population. Gennan = to produce This entry appears with permission from the … [adj] Medical Definition of Mutagenic. The Ames test is widely used test to detect possible chemical carcinogens. Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. ... mutagenicity: Definition: The property of a chemical that causes the genetic characteristics of an organism to change in such a way that future generations are permanently affected. Hop on to get the meaning of MUTA. Some of these cookies are essential to the operation of the site, while others help to improve your experience by providing insights into how the site is being used. Because of their mechanism of action germ cell mutagens are likely to have carcinogenic effects. Definition of Mutagenic. They include microbial, insect, mammalian cell, and whole animal tests. A.0.4.2 An exception to the above order or precedence is made for Carcinogenicity, Germ Cell Mutagenicity, and Reproductive Toxicity. What does Medical & Science MUTA stand for? Genotoxicity testing evaluates gene mutations, changes in chromosomes or DNA and gene toxicities caused by by-products or compounds over an extended period of time. genetic toxicology definition Genetic toxicology is the study of genetic damage to the hereditary material that results in genetic alterations. Rogers, in Sterilisation of Biomaterials and Medical Devices, 2012. Enrich your vocabulary with the English Definition … Learn more. UK spelling…. Glossaries for translators working in Spanish, French, Japanese, Italian, etc. Mutant frequencies and loss of heterozygosity induced by N-ethyl-N-nitrosourea in the thymidine kinase gene of L5178Y/TK+/–-3.7.2C mouse lymphoma cells. Origin: Gr. See more. Overall, there was a high correlation between structural alerts to DNA reactivity and mutagenicity, but the correlation of either property with carcinogenicity was low. The mutagenicity of acid halides has been tested in the Ames test, and therefore, they routinely appear in training and test sets. The Ames Mutagenicity test is used to determine the potential mutagenic activity of an extract from a medical device/material. Tests of chemical substances and physical agents for mutagenic potential. The mechanism of their activity has been investigated, and it has been determined that the solvent system plays a key role in the observed activity. Current Intelligence Bulletins (CIBs) are issued by the National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control, Atlanta, Georgia, to disseminate new scientific information about occupational hazards. These differences are caused by mutation or other types of cellular damage, and they're generally the first sign of a developing lesion, tumor or other disease. Legal browser? Definition of mutagen in the Legal Dictionary - by Free online English dictionary and encyclopedia. A list of translations of the expression "mutagenicity testing" and its definition. A collection of legal and legislative terms in Irish extracted from the European Union's multilingual terminology database. W.J. by AcronymAndSlang.com 1. The scope of this experimental study was the determination of the mutagenicity of the decoction and fresh ethanolic extract of Makahiya. capable of causing mutation ¹. Medical Author: William C. Shiel Jr., MD, FACP, FACR Enediyne: A very potent and naturally occurring antibiotic that acts by cleaving DNA. Ames test: A test developed in 1974 by Bruce N. Ames for identifying possible carcinogens by studying their mutagenic effect on bacteria.The Ames test is widely used test to detect possible chemical carcinogens. The Microbial mutagenicity Ames test is a bacterial bioassay accomplished in vitro to evaluate the mutagenicity of various environmental carcinogens and toxins. Glossary translations. The herb was gathered in Davao City and the extracts were prepared in Davao Medical School Foundation, Inc. laboratory, Dr. A. Gahol Street, Bajada, Davao City. The Medical & Science Acronym /Abbreviation/Slang MUTA means Mutagenicity. anaemia definition: 1. a medical condition in which there are not enough red blood cells in the blood: 2. If rodent carcinogenicity is regarded as a singular property of chems., then neither structural alerts nor mutagenicity to Salmonella are effective in its prediction. What are these term exactly? ... Mutagenicity and genotoxicity of water treated for human consumption induced by chlorination by-products. Definition of Mutagenic. Mutagenicity tests - Tests of chemical substances and physical agents for mutagenic potential. Medical Author: William C. Shiel Jr., MD, FACP, FACR Ames test: A test developed in 1974 by Bruce N. Ames for identifying possible carcinogens by studying their mutagenic effect on bacteria. Mutagenicity test - Tests of chemical substances and physical agents for mutagenic potential. Carcinogenicity of Acetaldehyde and Malonaldehyde, and Mutagenicity of Related Low-Molecular-Weight Aldehydes. A list of translations of the expression "mutagenicity" and its definition. Foci are cells located in a specific organ of the body that are notably different from the surrounding cells. Germ cell mutagenicity can act over several generations and cause problems like reduction of fertility, malformations, genetic diseases, embryonic death or genetically determined phenotypic alterations. ... consultation, or advice of a legal, medical, or any other professional. 1. (12 Dec 1998) Lexicographical Neighbors of Mutagenicity Tests Studies for predicting mutagenicity or carcinogenicity from the structure of chemical substances have been being conducted since a long time. Foreword. Training and test sets results in genetic alterations, and mutagenicity of acid halides has tested! Achieves this by inhibiting Ca 2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine.. Carcinogenicity of Acetaldehyde and Malonaldehyde, and control of disease in a specific organ of expression... 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